Phosphoprotein Phosphatase PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling

[摘要] Abstract Insulin (INS) metabolic signaling is important for normal cardiovascular and renal function as well as for exerting the classic actions of INS, such as glucose uptake in skeletal muscle tissue. There is emerging evidence that tyrosine phosphatases as well as protein kinases have important modulating roles in INS metabolic signaling in both cardiovascular and classically INSsensitive tissues. For example, increases in phosphatase activity may partially explain how angiotensin II and aldo.

[学科分类] 心脏病和心血管学

[关键词] Cell signaling;Hormones;Cytokines;Receptors