Effective T helper cell responses against retroviruses: are all clonotypes equal?
[摘要] ThecriticalimportanceofCD4+TcellsincoordinatinginnateandadaptiveimmuneresponsesisevidencedbythesusceptibilitytovariouspathogenicandopportunisticinfectionsthatarisesfromprimaryoracquiredCD4+Tcellimmunodeficiency,suchasfollowingHIV‐1infection.However,despitetheclearlydefinedrolesofcytotoxicCD8+Tcellsandantibodiesinhostprotectionfromretroviruses,theabilityofCD4+Tcellstoexertasimilarfunctionremainsunclear.RecentstudiesinvarioussettingshavedrawnattentiontothecomplexityoftheTcellresponsewithinandbetweenindividuals.DistinctTCRclonotypeswithinanindividualdiffersubstantiallyintheirresponsetothesameepitope.Functionallysimilar,“public”TCRclonotypescanalsodominatetheresponseofdifferentindividuals.TCRaffinityforantigendirectlyinfluencesexpansionanddifferentiationofrespondingTcells,alsolikelyaffectingtheirultimateprotectivecapacity.WiththisincreasingunderstandingoftheparametersthatdeterminethemagnitudeandeffectortypeoftheTcellresponse,wearenowbetterequippedtoaddresstheprotectivecapacityagainstretrovirusesofCD4+Tcellclonotypesinducedbynaturalinfectionorvaccination...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] CD4 T cell;TCR avidity;TCR diversity;immunological memory [时效性]
