RIP2 activity in inflammatory disease and implications for novel therapeutics

[摘要] TheroleofNOD2andRIP2ininflammatorydiseasehasbeenparadoxical.Whereasloss‐of‐functionNOD2polymorphismscauseCD,agranulomatousdiseaseofthegastrointestinaltract,gain‐of‐functionmutationscauseEOS—agranulomatousdiseaseprimarilyaffectingtheskin,joints,andeyes.Thus,gain‐of‐functionmutationsandloss‐of‐functionpolymorphismscausegranulomatousinflammatorydisease,onlyindifferentanatomiclocations.ThesituationiscomplicatedfurtherbythefactthatWTNOD2andWTRIP2activityhasbeenimplicatedindiseasessuchasasthma,inflammatoryarthritisandMS.ThisarticlereviewstherolethattheNOD2:RIP2complexplaysininflammatorydisease,withanemphasisontheinhibitionofthissignalingpathwayasanovelpharmaceuticaltargetininflammatorydisease...

[学科分类] 生理学

[关键词] NOD2;NF‐κB signaling;innate immunity;autoimmune disease;drug development;kinase inhibitor