Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease
[摘要] Inflammatoryboweldiseaseisassociatedwithanumberofcomorbiditiesthatariseatextraintestinalsites,includingthelung.Pulmonarymanifestationsreportedininflammatoryboweldiseaseincludebronchiectasis,chronicbronchitisandimportantly,arangeofsubclinicalrespiratoryabnormalitiesthatareoftenoverlookedinroutineclinicalevaluation.WhereasevidenceforthepulmonarymanifestationsofInflammatoryboweldiseaseisincreasing,littleisknownabouttheimmunologicandphysiologicmechanismsregulatingcross‐talkbetweenthegutandlungduringdisease.ThisreviewexaminesreportedlunginvolvementinInflammatoryboweldiseaseanddiscussesthepossibleimmunepathwaysthatunderliepulmonarypathologies.Thesemechanismsincludedysfunctionalimmune‐cellhoming,systemicinflammation,andmicrobialdysbiosis;allofwhichmaycontributetoInflammatoryboweldisease‐inducedpulmonaryinflammation.ThesemechanismsarediscussedinthecontextofourcurrentknowledgeofthesharedmucosalimmunesystemandtheimmunologyofInflammatoryboweldisease...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] lung;neutrophil;homing;T cells;microbiome [时效性]
