Mechanisms of Notch signaling specificity in lymphocytes and their leukemic counterparts

[摘要] Signaling pathways have evolved to ensure that external signals are sensed by a cell and translated into changes in gene expression,that ultimately determine the differentiation and function of a cell. Mutations in components of signaling pathways uncouple,these from the external signals they normally respond to, and thereby constitutively (in)activate these pathways, which can,lead to disease, most notably cancer. In this thesis, we studied the role of one such pathway, Notch signaling, in the differentiation,and function of lymphocytes and their leukemic counterparts.

[发布机构] University of Amterdam