Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application

[摘要] Recent progress in tissue engineering research led to the generation of different types of cells from a handful of skin tissue. Lineage reprogramming is a nascent field, which holds great potential to expand its use in regenerative medicine and disease modeling. The concept of somatic cell epigenetic stability has been fundamentally reshaped through the report of direct conversion of somatic identity to another lineage by introducing transcription factors. Here, we review recent advances in lineage reprogramming research, especially direct conversion into dopamine neurons from fibroblasts.

[学科分类] 皮肤病学

[关键词] Direct conversion;Dopamine neurons;Fibroblasts and iPSC