The Use of Corpus Callosum index in The Measurement of Brain Atrophy in Multiple sclerosis

[摘要] Background: Corpus callosum is one of the few white matter tracts that can be discretely identified by conventional MRI. Many studies have proved the role of corpus callosum involvement in the disability in multiple sclerosis patients. Objective: To evaluate corpus callosum atrophy in patients with multiple sclerosis in comparison to global brain atrophy and its relation to clinical disability. Methods: forty two patients with multiple sclerosis and 32 health age and sex matched controls were included in this study. MS was diagnosed according to McDonald’s criteria. Magnetic resonance imaging was performed for both patients and controls. Measurement of corpus callosum index and intercaudate ratio was performed for both patients and controls. Results: CCI was significantly lower in patients compared to controls. CCI was significantly correlated to EDSS scores and ICR (p>0.05) but not to the duration of illness nor to the age of onset of disease. There were no significant differences in CCI when comparing RRMS to SPMS and Males to females. Conclusion:  Corpus callosum index is a practical, easy and feasible test to measure brain atrophy in MS patients. [Egypt J Neurol Psychiat Neurosurg.  2010; 47(4): 633-637]

[学科分类] 精神健康和精神病学