Traumatic Brain Injuries

[摘要] Background: Recent studied proved efficacy of cerebrolysin in dementia and Alzheimer, although studies on traumatic brain injuries still limited. Objective: Investigating the efficacy of cerebrolysin as a neurotrophic drug on the prognosis and morbidity of TBI patients. Methods: Forty TBI patients were divided into 2 equally matched groups, group1 received cerebrolysin for 20 days plus other conventional therapy, and group 2 received only conventional therapy as a control group. Both groups were subjected to GCS, APATCHE II scores and CT brain on admission, and on day twenty, followed by comparing the degree of improvement in each group on day twenty to day one scores. Results: Patients on cerebrolysin compared to the control group on admission had no statistically significant difference as regards GCS, while on day 20 the GCS scores showed a significant difference between both groups (p-value= 0.045). There was a significant increase in GCS score on day 20 than GCS on day one in patients on cerebrolysin, p -value= 0.001 as compared to patients on conventional therapy p-value= 0.79. There was highly significant negative correlation between GCS difference and APACHE II scores in both group 1 & 2 as the p-value ≤ 0.05. Conclusions: The use of cerebrolysin as part of the initial management of head trauma is effective in improving the clinical status of patients with TBI after 20 days. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(1): 43-48]

[学科分类] 精神健康和精神病学