Time after time: biological factors in the course of recurrent depression

[摘要] The primary focus of this dissertation was to increase the knowledge about possible biological factors and psychopathological,mechanisms (including HPA-axis functioning, one-carbon and fatty-acid metabolism), as well as some gene-environment interactions,for the course of recurrent MDD (MDD-R). Studying MDD-R is important because there are indications that it represents a more,biological and genetic determined MDD-subtype, which may be specifically linked to recurrence and CVD-risk. For this reason,we expected these patients to deviate the strongest from healthy controls in the (patho)physiological and genetic mechanisms,and to have more pronounced alterations in their course of MDD.

[发布机构] University of Amterdam