Die Rolle der Umwelt bei der Entstehung der caninen atopischen Dermatitis

[摘要] Canine and human atopic dermatitis (AD) are multifaceted diseases which clinicaldevelopment may be influenced by several factors such as genetic background,environment, secondary infections, food and psychological effects. The role of theenvironment has been extensively examined in humans but remains unclear in dogs.The aim of the present study is to examine environmental factors in 2 geneticallyclose breeds: Labrador and Golden Retrievers. Using standard criteria, atopic dogswere selected and compared to healthy individuals. Information on environmentalfactors was collected using a questionnaire. Univariate and multivariable logisticregression was subsequently used in order to assess the association between allpotential risk factors and the disease status.The following parameters, resulting from the multivariable logistic regression, wereassociated with an increased risk of disease development: living in a shed duringpuppyhood, adoption at the age of 8 to 12 weeks and washing the dog regularly. Onthe contrary, the following factors were associated with a lower risk: living in a ruralenvironment, living in a household with other animals and walking in the forest.These associations do not prove causality but support the primary hypothesis thatcertain environmental factors may influence canine AD development. Further studiesare warranted to confirm the current results and conclusions.

[发布机构] University of Zurich

[效力级别] Department of Farm Animals

[关键词] Department of Small Animals;Department of Farm Animals;570 Life sciences;biology;630 Agriculture