Role of the M1 receptor in regulating circadian rhythms

[摘要] Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M-1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms. (C) 2001 Elsevier Science Inc. All rights reserved.

[发布日期] 2001-04-27

[效力级别]  Proceedings Paper

[关键词] acetylcholine;cGMP/PKG signaling;circadian rhythms;muscarinic receptors;suprachiasmatic nucleus