Liriodendrin, ameliorates hypertension by calcium channel blockade and enhancing enos expression in wistar rats

[摘要] Hypertension is found to be the prime cause of death worldwide in spite of a number of available treatments which suggests that there is a need of discovering new lead molecules that would be more effective to treat cardiovascular disease (CVD). Liriodendrin, the lignan phytoconstituent possesses potential pharmacological effects. Literature survey suggests that liriodendrin could be effective in mitigating hypertension considering its structural similarity with reported cardiovascular protective drugs. Hence liriodendrin is investigated to reveal its mechanism of actions to support its antihypertensive property.

[学科分类] 环境科学（综合）

[关键词] DOCA;Hypertension;Endothelial dysfunction;Oxidative stress;Liriodendrin