Multi-Nutrient Supplement Ameliorates Diabetic Nephropathy in Rats

[摘要] Aim: Although multinutrients are widely used as dietary supplements to maintain health, the effects of these products were not investigated in diabetic nephropathy. Therefore, in this study we investigated renal protective effect of the multinutrient supplement in diabetic rats. Diabetes was induced in male Wistar rats by administration of streptozotocin (52mg/kg,i.p). The diabetic rats were then treated with multi-nutritional supplement for 6 weeks. After 6 weeks, body weight, fasting serum glucose, glycosylated haemoglobin, kidney function tests and renal antioxidant enzymes were determined. Treatment with multinutrient supplement showed significant increase in the body weight and creatinine clearance, accompanied by a significant decrease in kidney index, blood glucose levels and glycosylated hemoglobin. Further, the treatment significantly prevented the depletion of renal antioxidant enzyme activity and significantly reduced lipid peroxidation in diabetic rats. Thus, our findings indicate that multinutrient therapy can be a promising approach to delay the development of diabetic nephropathy. Aim: Although multinutrients are widely used as dietary supplements to maintain health, the effects of these products were not investigated in diabetic nephropathy. Therefore, in this study we investigated renal protective effect of the multinutrient supplement in diabetic rats. Diabetes was induced in male Wistar rats by administration of streptozotocin (52mg/kg,i.p). The diabetic rats were then treated with multi-nutritional supplement for 6 weeks. After 6 weeks, body weight, fasting serum glucose, glycosylated haemoglobin, kidney function tests and renal antioxidant enzymes were determined. Treatment with multinutrient supplement showed significant increase in the body weight and creatinine clearance, accompanied by a significant decrease in kidney index, blood glucose levels and glycosylated hemoglobin. Further, the treatment significantly prevented the depletion of renal antioxidant enzyme activity and significantly reduced lipid peroxidation in diabetic rats. Thus, our findings indicate that multinutrient therapy can be a promising approach to delay the development of diabetic nephropathy.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Diabetic nephropathy;Streptozotocin;Multi-nutritional supplement;Kidney function.