The Evaluation of Intestinal Permeability in Preeclamptic Pregnancy

[摘要] Background: Zonulin is a physiological protein that regulates the tight connections and permeability of the intestine, serving as a biomarker for impaired intestinal permeability. Objective: The aim of this study was to examine zonulin levels in preeclampsia, to investigate its associations with the cellular immune response marker soluble interleukin-2 receptor (sIL-2R) and exogenous antigen load marker lipopolysaccharide binding protein (LBP) and to evaluate the implications of these findings in the etiopathogenesis of preeclampsia. Methods: We designed a cross-sectional case-control study and enrolled 22 pregnant women with preeclampsia and 22 healthy pregnant controls. Plasma zonulin levels were determined by ELISA. Serum sIL-2R and LBP levels were assessed by chemiluminescent immunometric methods.

[学科分类] 社会科学、人文和艺术（综合）

[关键词] preeclampsia;intestinal permeability;zonulin;lipopolysaccharide binding protein;IL-2 receptor.