An audit on muscle biopsies in a tertiary care centre in Sri Lanka

[摘要] Introduction: Novel diagnostic methods in the diagnosis of paediatric liver diseases have developedrapidly, including electron microscopy, imaging, serology, and genetic studies. Nevertheless,conventional diagnostic methods like liver biopsy continue to play a pivotal role.Method: The clinical diagnosis and histological diagnosis of liver biopsies received at Lady RidgewayHospital were reviewed during a one-year period beginning from 01st March 2020. These werecategorized as: Category 1 - non diagnostic (due to inadequate or unsatisfactory specimens), Category2 - neither exclude/confirm the clinical diagnosis nor provide prognostic or therapeutic information(e.g. descriptive reports), Category 3 - confirms the clinical diagnosis but does not provide furtherinformation such as aetiology, Category 4 - confirms the clinical diagnosis and provides furtherinformation important for patient management and Category 5 - changes the clinical diagnosiscompletely. Thus, categories 1 and 2 were deemed as having no impact on the management of thepatient, while categories 3, 4, and 5 were considered as valuable in the management of the patient.Results: There were 61 liver biopsies. No unsatisfactory/inadequate samples were received (Category1). Only 8.2% (5/61) of the biopsies generated descriptive reports (Category 2). 29% (18/61) liverbiopsies confirmed the clinical diagnosis without providing additional information (Category 3) and42% (26/61) of the biopsies provided further useful information (Category 4). The histology changedthe clinical diagnosis in 20% (12/61) of the biopsies (Category 5).Conclusion: 92% (56/61) of the biopsies had a significant impact on the diagnosis and management ofpaediatric liver diseases.

[学科分类] 生理学与病理学