Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations

[摘要] Chromosomal translocations result from the interchange of genetic material between non-homologous chromosomes. Chromosomal translocations are formed byerroneous repair of double-stranded breaks (DSBs) vianon-homologous end joining (NHEJ) [1]. Some genotoxicdrugs produce DSBs and thus present a major risk factorfor the development of oncogenic chromosomal translocations. The risk factors that interfere with translocationprone DSB repair, once DSBs are already formed, areobscure, and potential effects of drugs on translocationformation during this step have never been explored.

[学科分类] 社会科学、人文和艺术（综合）