Social-epigenetic mediators for racial disparities in pulmonary impairment among childhood cancer survivors

[摘要] Previous research found that childhood cancer survivorsof African ancestry have significantly higher morbidity and mortality than those of European ancestry [1].However, after adjusting for socio-economic factors, themagnitudes of racial health disparities are either substantially decreased or become statistically non-significant [1],suggesting that social and economic determinants maycontribute to racial health disparities. Recently, we conducted epigenome-wide association studies (EWAS) forthree key social determinants of health (SDOHs), namely,personal educational attainment, personal income, andneighborhood deprivation among survivors of childhoodcancer, where 130 epigenome-wide significant SDOH-CpGassociations were identified among European ancestry survivors, and 25 of which were also validated in Africanancestry survivors [2]. Notably, many SDOH-associatedCpG sites are also associated with tobacco use.

[学科分类] 社会科学、人文和艺术（综合）