p21 is necessary for the beneficial effects of fasting during chemotherapy

[摘要] Short-term fasting (up to 48 hours) activates strongphysiological and molecular responses [1]. We and others showed a p53-independent transcriptional activation ofthe cell cycle inhibitor p21 upon fasting, most strongly inthe liver, muscles, and many other tissues [2, 3]. Studieswith mice [4, 5] and human patients [6] have shown thebeneficial effects of short-term fasting during anti-cancerchemotherapy treatments.

[学科分类] 社会科学、人文和艺术（综合）