Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non-small cell lung cancer patients with brain metastasis

[摘要] The scarcity of routine metastatic biopsies or resection limits the finding of biomarkers of diagnosis and prognosisin patients with brain metastases. Derived from necrosis,apoptosis, and secretion of tumor cells, circulating tumorDNA (ctDNA) is widely distributed in various body fluids,including peripheral blood and cerebrospinal fluid (CSF),as an alternative biomarker for tumor-associated analysis[1]. Fortunately, genomic alterations of blood ctDNA andCSF ctDNA have been proven as prognostic markers innon-small cell lung cancer (NSCLC) patients with brainmetastasis [2, 3].

[学科分类] 社会科学、人文和艺术（综合）