Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis

[摘要] Accumulating evidence suggests that dysregulated lysosomal membrane proteins, including vacuolar ATPase (vATPase) and the mammalian target of rapamycin (mTOR),are involved in tumorigenesis [1]. Therefore, lysosomalproteins were proposed as potential therapeutic targetsin cancer [1]. As one of the lysosome-related signalingpathways, mTOR signaling regulates cell proliferation,survival, motility, and metabolism [2]. Since mTOR signaling activation promotes tumorigenesis, mTOR inhibitors(mTORi), AZD8055 [3], MLN0128 [4], and Rapalink-1 (thelatest third-generation mTORi) [4], have been appliedto several cancers. However, the limitations of mTORiinclude drug resistance and the lack of biomarkers.

[学科分类] 社会科学、人文和艺术（综合）