A Heinous Review On Inquiry Of Drug Interactions Among Hypertensive Patients Taking Antihypertensive Agents.

[摘要] Hypertension (HT), which is defined as a chronic elevation of systolic and/or diastolic blood pressure(BP), is in all probability the most common chronic disease today. Drug interactions occur when the effect ofone drug is altered by the co administration of another. Such alterations may result either from changes in thedrug's concentration (pharmacokinetic interaction) or from changes in the drug's effect independent ofconcentration (pharmacodynamics interaction). Several studies have shown age-related reduction in livermetabolism of many drugs. These changes significantly influence pharmacokinetics. Polypharmacy is commonin the elderly. It is estimated that more than 40% of persons aged 65 or older use 5 or more, and 12% use 10 ormore different medications. The previous studies which included younger hypertensive patients identified upto 48% of patients with potential interactions of high significance.22 This difference in incidence of interactionis a consequence of comorbidity and polypharmacy which occur in elderly patients. Many studies emphasisethe importance of monitoring of potential drug interactions in elderly patients with arterial hypertension.Fortunately, majority of these interactions can be managed by clinical and laboratory monitoring of patients orby dosage adjustments of one or both agents.

[学科分类] 工程和技术（综合）

[关键词] Hypertension;drug interaction;pharmacokinetic interaction;pharmacodynamics interaction