Cobalt (II) and Vanadium (IV, I) Complexes based on Semicarbazide derivatives: Spectroscopic and DNA binding Studies.

[摘要] Cobalt and Vanadium complexes with a tridentate (O-N-O) based ligand 2- hydroxynaphthaldehydehydrazinecarboamide (1) and 3-ethoxy-2- hydroxybenzaldehyde hydrazinecarboamide (2) have been1 13 synthesized. The synthesized ligands were structurally characterized by FTIR, HNMR and CNMR spectroscopy.The complexes were characterized by Energy Dispersive X-ray Spectrometry (EDX). The structures of vanadium51 51 complexes were also confirmed by V-NMR. Based on the V-NMR results, the vanadium revealed two differentoxidation states in complexing systems with the ligands 1 and 2. The activity of ligand and complexes toward theDNA interaction was investigated using UV spectra and viscosity measurement. The results showed theintercalative binding mode of the ligands and complexes with DNA.

[学科分类] 工程和技术（综合）

[关键词] Semicarbazide;V-NMR;EDX;DNA;Viscosity