Increased Levels of Spinal Cord KIF1B Protein In Healthy and Diabetic Neuropathic Wistar Rats With in Adaptation to Aerobic Training (KIF1B Changes in Sensory Neurons After Exercise)

[摘要] Background and Objectives Diabetic neuropathy is one of the most common complications of diabetesand no suitable drug treatment has been found for this complication. The aim of this study was to determinethe effect of six weeks of aerobic exercise on KIF1B protein in the sensory part of the spinal cord inrats with diabetic neuropathy.Subjects and Methods In the present experimental study, 12 male Wistar rats were divided into 4 groups:healthy exercise, control exercise, healthy diabetes and control diabetes. The training program included6 weeks of running training on the treadmill in 5 sessions per week. The dorsal part of the spinal cordwas analyzed as sensory neurons.Results The results showed that aerobic exercise significantly reduced blood glucose in the diabeticgroup compared to the control diabetes group (P=0.002), but no significant difference was observed inthe weight of rats. The results also showed that a significant increase (P=0.044) in KIF1B in healthy exercisegroup compared to healthy control group and a significant increase (P=0.027) in KIF1B in diabeticexercise group compared to control diabetes.Conclusion The results showed that aerobic exercise increases the amount of KIF1B protein in healthyand diabetic rats, and this increase in KIF1B motor protein can improve axonal transmission and thusimprove nerve function.

[学科分类] 基础医学

[关键词] Diabetic Neuropathy;aerobic training;KIF1B