Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease

[摘要] Background - Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. Methods and Results - The present randomized, multicenter, prospective study compared the use of long (>= 32 mm) SES with PES in 500 patients with long (>= 25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9 +/- 11.6 mm in the SES group and 34.5 +/- 12.6 mm in the PES group (P = 0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3% versus 14.6%; relative risk 0.23; P < 0.001). In-stent late loss of lumen diameter was 0.09 +/- 0.37 mm in the SES group and 0.45 +/- 0.55 mm in the PES group (P < 0.001). In patients with restenoses, a pattern of focal restenosis was more common in the SES group than in the PES group (100% versus 53.3%, P = 0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4% versus 7.2%, P = 0.012). The incidence of death (0.8% in SES versus 0% in PES, P = 0.499) or myocardial infarction (8.8% in SES versus 10.8% in PES, P = 0.452) at 9 months of follow-up was not statistically different between the 2 groups. Conclusions - For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation.

[关键词] RANDOMIZED CONTROLLED-TRIAL;RESTENOSIS;IMPLANTATION;LESIONS;REVASCULARIZATION;METAANALYSIS;ANGIOPLASTY;PREDICTORS;THROMBOSIS;CARDIOLOGY