Correlation between Group B Streptococcal Genotypes, Their Antimicrobial Resistance Profiles, and Virulence Genes among Pregnant Women in Lebanon

[摘要] The antimicrobial susceptibility profiles of 76Streptococcus agalactiae(Group B Streptococci [GBS]) isolates from vaginal specimens of pregnant women near term were correlated to their genotypes generated by Random Amplified Polymorphic DNA analysis and their virulence factors encoding genescylE, lmb, scpB, rib, andbcaby PCR. Based on the distribution of the susceptibility patterns, six profiles were generated. RAPD analysis detected 7 clusters of genotypes. ThecylEgene was present in 99% of the isolates, thelmbin 96%,scpBin 94.7%,ribin 33%, andbcain 56.5% of isolates. The isolates demonstrated a significant correlation between antimicrobial resistance and genotype clusters denoting the distribution of particular clones with different antimicrobial resistance profiles, entailing the practice of caution in therapeutic options. All virulence factors encoding genes were detected in all seven genotypic clusters withribandbcanot coexisting in the same genome.

[学科分类] 微生物学和免疫学