Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells:In VitroandIn VivoStudies

[摘要] Due to its abundance, easy retrieval, and plasticity characteristics, adipose-tissue-derived stromal cells (ATSCs) present unquestionable advantages over other adult-tissue-derived stem cells. Based on thein silicoanalysis of our previous data reporting the ATSC-specific expression profiles, the present study attempted to clarify and validate at the functional level the expression of the neurospecific genes expressed by ATSC bothin vitroandin vivo. This allowed evidencing that ATSCs express neuro-specific trophins, metabolic genes, and neuroprotective molecules. They were in fact able to induce neurite outgrowthin vitro, along with tissue-specific commitment along the neural lineage and the expression of the TRKA neurotrophin receptorin vivo. Our observation adds useful information to recent evidence proposing these cells as a suitable tool for cell-based applications in neuroregenerative medicine.

[学科分类] 基础医学