THE GENETICS OF α-HYDROXYACID OXIDASE AND ALCOHOL DEHYDROGENASE IN THE MOUSE: EVIDENCE FOR MULTIPLE GENE LOCI AND LINKAGE BETWEEN Hao-2 AND Adh-3

[摘要] Electrophoretic polymorphisms for stomach alcohol dehydrogenase (ADH-C2) and kidney L-α-hydroxyacid oxidase (HAOX-B4) have been identified in an Asian subspecies of mouse, Mus musculus castaneous . These variants are inherited in a normal Mendelian fashion with two alleles in each case showing codominant expression. The structural gene loci for those enzymes ( Adh-3 and Hao-2 , respectively) are apparently linked (17.6% recombinants) in this organism, whereas the multiple gene loci for HAOX, Hao-1 (encoding the A4 liver isozyme) and Hao-2 , exhibited independent segregation and are unlinked (50% recombinants). Evidence is presented for 3 ADH loci: Adh-1 , encoding liver ADH-A2 which exhibits high activity with ethanol (Selander, Hunt and Yang 1969; Adh-2 , liver and stomach ADH-B 2 using 2-hexene-1-ol as substrate; and Adh-3 , stomach ADH-C 2 using both benzyl alcohol and 2-hexene-1-ol as substrate.

[学科分类] 医学（综合）