A CHROMOSOMAL TRANSLOCATION CAUSING OVERPRODUCTION OF ISO-2-CYTOCHROME c IN YEAST

[摘要] The CYC7-1 mutation in the yeast Saccharomyces cerevisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c . Genetic analysis established that the CYC7-1 mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVI . The chromosome V arm was broken adjacent to the gene CYC7 , which determines the primary structure of iso-2-cytochrome c , and this fragment containing the CYC7 gene was joined to the segment of chromosome XVI . It appears as though the elevation of iso-2-cytochrome c is caused by an abnormal controlling region adjacent to the structural region of the CYC7 gene.

[学科分类] 医学（综合）