GENETIC VARIATION AT A LOCUS (TAM-1) FOR SUBMAXILLARY GLAND PROTEASE IN THE MOUSE AND ITS LOCATION ON CHROMOSOME 7

[摘要] Electrophoretic and activity variants for a testosterone-induced esteroprotease have been discovered in submaxillary glands from inbred strains of mice. The enzyme is tentatively designated tamase (TAM-1) and the variant genetic locus is Tam-1 . The alleles Tam-1a and Tam-1b determine electrophoretically distinct zones of tamase activity, while Tam-1c produces no detectable enzyme activity. Data from recombinant inbred strains and B6AF1 x B6 and B6D2F1 x B6 backcrosses established linkage of Tam-1 to glucose phosphate isomerase ( Gpi-1 ), pink-eyed dilution ( p ) and β-hemoglobin ( Hbb ) on chromosome 7 . The gene order is Gpi-1—Tam-1—p—Hbb . Analysis of congenic resistant strains indicates that Tam-1 is closely linked to the minor histocompatibility locus, H-4 . TAM-1 was not cross-reactive with antisera to mouse nerve growth factor, submaxillary renin, or tamases A and D.

[学科分类] 医学（综合）