Role of ETS Family Transcription Factors in Vascular Development and Angiogenesis

[摘要] References(53)Cited-By(47)The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] vasculogenesis;angiogenesis;transcription factor;ETS