Suppressive Effect of Antibiotics on Colony Formation from Human Megakaryocyte Progenitors (CFU-M) and Granulocyte-Macrophage Progenitors (CFU-GM)

[摘要] References(18)Cited-By(1)β-Lactam antibiotics, moxalactam (LMOX), cefotaxime (CTX), flomoxef (FMOX), cefamandole (CMD), carbenicillin (CBPC) and sulbenicillin (SBPC), suppressed colony formation from human megakaryocyte progenitors (CFU-M) and granulocyte-macrophage progenitors (CFU-GM) dose-dependently. The suppressive potencies for both progenitors were weakest for CBPC and SBPC, moderate for LMOX and FMOX, and strongest for CMD and CTX. The stainability of glycoprotein IIb/IIIa complex in the megakaryocyte colonies by the monoclonal antibody was decreased by LMOX and CTX. These data suggest that β-lactam antibiotics directly suppress proliferation of CFU-M and CFU-GM.

[学科分类] 药理学