Effects of Xanthine Derivatives on Phosphatidylcholine Secretion in Primary Culture of Rat Type II Pneumocytes

[摘要] References(10)Cited-By(5)Xanthine derivatives, pentoxifylline, aminophylline, theophylline and chinoin-170, increased phosphatidylcholine secretion in a primary culture of rat type II pneumocytes. However, these xanthines alone had no effect on intracellular cAMP levels in type II pneumocytes. In contrast, terbutaline-induced secretion of phosphatidylcholine was augmented by these xanthines, and the augmentation depended on the increase of cAMP levels. These results suggest that the xanthines induce phosphatidylcholine secretion possibly through cAMP-dependent and cAMP-independent pathways in the primary culture of rat type II pneumocytes.

[学科分类] 药理学

[关键词] Xanthine;Type II pneumocyte;Phosphatidylcholine secretion