Is Compensatory Vasoconstrictor Tone in the Hindquarter Vascular Region Induced by Hemorrhage in Conscious Spontaneously Hypertensive Rats?

[摘要] References(16)We investigated whether a compensatory vasoconstrictor action would be induced by a hypotensive intervention in the hindquarter vascular region of conscious spontaneously hypertensive rats (SHRs). Mean arterial pressure and hindquarter blood flow were recorded. After hemorrhage (withdrawing blood, 0.3 ml/100 g body weight), hindquarter resistance (HQR) was increased significantly. The decrease in HQR induced by the administration of a ganglionic blocker (C6; 25 mg/kg, i.v.) was significantly greater in SHRs with hemorrhage than in those without hemorrhage. The present results suggest that a detectable hindquarter compensator tone occurs due to hemorrhage in SHRs, although an abnormal substantial vasoconstrictor tone already exists in the hindquarters.

[学科分类] 药理学

[关键词] Hemorrhage;Hindquarter compensator;Spontaneously hypertensive rat