Voltammetric determination of amitriptyline in pharmaceutical formulation with boron-doped diamond electrode exploiting measures in acid medium

[摘要] A simple and reliable voltammetric method is presented for the determination of amitriptyline using a boron-doped diamond electrode in 0.1 mol L–1 sulfuric acid solution as the support electrolyte. Under optimized differential pulse voltammetry conditions (modulation time 5 ms, scan rate 70 mV s–1, and pulse amplitude 120 mV), the electrode provides linear responses to amitriptyline in the concentration range 1.05 to 92.60 µmol L–1 and at a detection limit of 0.52 µmol L–1. The proposed method was successfully applied in pharmaceutical formulations, with results similar to those obtained using UV–vis spectrophotometric method as reference (at 95% confidence level), as recommended by the Brazilian Pharmacopoeia.

[学科分类] 化学（综合）

[关键词] differential pulse voltammetry;quality control;BDDE;tricyclic antidepressant.