Hypofractionated radiotherapy and adjuvant chemotherapy do not increase radiation-induced dermatitis in breast cancer patients

[摘要] Purpose Radiation-induced dermatitis is a common side effect of breast irradiation, with hypofractionation being a well known risk factor. In the context of the widespread adoption of hypofractionated breast radiotherapy, we evaluated the effect of hypofractionated radiotherapy on the incidence of skin toxicity in patients receiving adjuvant chemotherapy. Patients and Methods We retrospectively reviewed the records of patients with breast cancer treated from 2004 to 2006 at a single institution. Patients undergoing lumpectomy with or without adjuvant chemotherapy followed by hypofractionated radiotherapy consisting of 42.4 Gy in 16 fractions were included in the study. Using cosmetic and skin toxicity scales, all patients were evaluated weekly during treatment and at scheduled follow-up visits with the radiation oncologist. Results During the study period, 162 patients underwent radiotherapy, and 30% of those ( n= 48) received chemotherapy. Radiotherapy boost to the tumour bed was more common in the chemotherapy group [ n= 20 (42%)] than in the radiotherapy-alone group [ n= 30 (26%)]. We observed no statistically significant difference between the groups with regard to acute skin toxicity of grade 3 or higher (2.1% in the chemotherapy group vs. 4.4% in the radiation alone group,p= 0.67) or of grades 1-2 toxicity (62.5% vs. 51.7% respectively,p= 0.23). There was also no significant difference in late grade 3 or higher skin toxicity between the groups (2.1% vs. 0% respectively,p= 0.30) or in grades 1-2 toxicity (20.8% vs. 25.5% respectively,p= 0.69). Similarly, excellent or good cosmetic result scores were similar in both groups ( p= 0.80) Conclusions In our single-institution review, we observed no adverse effects of chemotherapy in combination with hypofractionated whole-breast irradiation. Further investigations are necessary to better elucidate the effects of chemotherapy on skin toxicity in the context of hypofractionated irradiation. Purpose : Radiation induced dermatitis is a common side effect of breast irradiation, with hypofractionation being a well-known risk factor. In the context of the widespread adoption of hypofractionated breast radiotherapy, we set to evaluate the impact of hypofractionated radiotherapy on the incidence of skin toxicity in patients receiving adjuvant chemotherapy.Materials & Methods : We conducted a retrospective review of patients with breast cancer treated from 2004 to 2006 at a single institution . Patients undergoing lumpectomy with or without adjuvant chemotherapy followed by hypofractionated radiotherapyconsisting of 42.4 Gray in 16 fractionswere included in this study. All patients were evaluated weekly during treatment and on scheduled follow-up visits by the radiation oncologist using the RTOG/EORTC skin radiation toxicity scale version 2. Results : 162 patients underwent radiotherapy during the study period, 30% (n=48) of which received chemotherapy. Radiotherapy boost to the tumor bed was more common in the chemotherapy group (n=20; 42% of patients) compared to the radiotherapy alone group (n=30; 26%). There was no statistically significant difference between the two groups with regards to acute skin toxicity of grade ?3 (2.1% in the chemotherapy group vs. 4.6% in the radiation alone group; p=0.67 )or grade 1-2 (63.7% vs. 54.2%, respectively; p=0.23). With regards to late skin toxicity, there was, again, no significant difference between the chemotherapy and the radiation alone group for grade ?3 (0% vs. 2.6% respectively; p=0.29) or grade 1-2 toxicity (26.3% vs. 31.2% respectively; p=0.68). Similarly, cosmetic results were similar in both groups (p=0.76) Conclusion : In our single institution review, there was no adverse affect of chemotherapy to hypofractionated whole breast irradiation. Further investigations are necessary to better elucidate the impact of chemotherapy on skin toxicity in the context of hypofractionated irradiation.

[学科分类] 肿瘤学