Formulation and in-vitro evaluation of self microemulsifying drug delivery system (SMEDDS) of Furosemide

[摘要] Aim of the present investigation was to develop the Self Microemulsifying Drug Delivery System (SMEDDS) of Furosemide. Furosemide is Class IV molecule according to BCS (Biopharmaceutical Classification System), having low solubility and low permeability. Prepared optimized SMEDDS of Furosemide composed of CAPTEX 500 as oil and Cremophore EL as surfactant in 20:80 ratio. Optimized SMEDDS of Furosemide showed increase in dissolution rate of Furosemide in Simulated Gastric Fluid (SGF) and 5.8 pH phosphate buffer, irrespective of pH compared the Marketed Tablet LASIX Ò (Furosemide 40 mg)

[学科分类] 药理学