Use of Mouse Serum in Identification and Serologic Classification of Rickettsia Akari and Rickettsia Australis

[摘要] 1. 1. Following infection with R. akari or R. australis , Swiss mice developed species-specific antibody which, unlike guinea pig convalescent sera, did not fix complement with the soluble, cross-reacting antigen of heterologous rickettsias of the spotted fever group.2. 2. The EM rickettsia, a newly described agent recovered from ticks from eastern Montana, also produced highly specific CF antibody in mice. Cross-reactions were not observed between the EM agent and any of the members of the spotted fever group tested.3. 3. Species-specific antibody was produced in mice by other agents of the group, i.e., R. rickettsi, R. conori and R. siberica . Yet, because of the extremely large dose of these rickettsias required and the erratic results obtained, these studies are regarded as preliminary only.4. 4. Toxin-neutralizing, but not CF, antibody could be detected in sera of mice inoculated with relatively low doses of live or inactivated R. rickettsi .

[学科分类] 生物科学（综合）