Relation Between Arterial Blood Pressure and Blood Volume and Effect of Infused Albumin in Sick Preterm Infants

[摘要] The relation between directly measured arterial blood pressure and blood volume was studied in 61 sick preterm infants. Mean blood volume (derived from plasma volume [T1824 ten-minute albumin space] and hematocrit value) of 26 hypotensive infants (89.1 ± 17.26 ml/kg) was not significantly different from that of 35 normotensive, but otherwise comparable, infants (91.4 ± 14.57 ml/kg). There was no relation between arterial mean blood pressure and blood volume.Twenty-one infants with arterial mean blood pressure less than 30 mm Hg were given 1.0 g/kg of 10% salt-poor albumin. Significant increases in blood pressure occurred but were small in magnitude; more than one half of infants had arterial mean blood pressures persistently less than 30 mm Hg. Arterial/alveolar Po2 ratio decreased significantly with albumin infusion in six infants with hyaline membrane disease not receiving continuous distending-airway pressure, suggesting an association between infused albumin and impaired oxygen exchange.

[学科分类] 儿科学