Persistent Increase in Aspartate Aminotransferase in an Asymptomatic Patient

[摘要] A 66-year-old woman without a preexisting history of liver disease presented with chest discomfort and dyspnea. Laboratory studies revealed an isolated increase in aspartate aminotransferase (AST)1 that prompted consultation with a hepatologist. The patient was a retired schoolteacher and took no medications. She affirmed alcohol use estimated at <2 oz of spirits daily.A physical examination revealed a healthy-appearing woman with no obvious abnormalities. The sclerae were anicteric. The abdomen was soft, flat, and without palpable organomegaly. There was no edema.Laboratory studies revealed the following: AST, 544 U/L (reference interval, 11–47 U/L); albumin, 38 g/L (36–50 g/L), alanine aminotransferase (ALT), 23 U/L (7–53 U/L); alkaline phosphatase (ALP), 95 U/L (38–126 U/L); total bilirubin, 4.0 mg/L (3.0–11 mg/L); direct bilirubin, 2.0 mg/L (0.0–3.0 mg/L); γ-glutamyltransferase (GGT), 25 U/L (11–50 U/L); lactate dehydrogenase (LDH), 373 U/L (100–250 U/L); hemoglobin, 139 g/L (121–151 g/L); reticulocytes, 0.008 (0.005–0.015); haptoglobin, 0.97 g/L (0.27–2.20 g/L); thyroid-stimulating hormone, 3.60 mIU/L (0.35–5.50 mIU/L); antinuclear antibodies, reactive at 1:80 (negative); anti–smooth muscle antibodies, reactive at 1:80 (<1:20); antimitochondrial antibodies, negative; α1-antitrypsin, 1.67 g/L (0.7–2.1 g/L); ferritin, 202 mg/L (10–291 mg/L); ceruloplasmin, 380 mg/L (180–460 mg/L); hepatitis B surface antigen, nonreactive; anti–hepatitis C virus, nonreactive; aldolase, 4.5 U/L (<8.0 U/L); and creatine kinase (CK), 116 U/L (38–234 U/L). The results of radiographic studies, including abdominal and chest computed tomography scans were unremarkable. Given the isolated increase in AST without signs or symptoms of liver disease, the patient was advised to discontinue alcohol consumption, and the clinical laboratory was contacted for additional studies.### increases in the results of liver function testsTests for liver “function” consist of those for aminotransferases (ALT and AST), bilirubin, ALP, LDH, GGT, albumin, and prothrombin time (1). Of these tests, only albumin, bilirubin, and prothrombin time truly assess hepatic function. For other functions of the liver, such as drug metabolism, …

[学科分类] 过敏症与临床免疫学