Three‐dimensional structure of monoanionic methionine‐enkephalin: X‐ray structure of tert‐butyloxycarbonyl‐Tyr‐Gly‐Gly‐(4‐bromo)Phe‐Met‐OH

[摘要]

The conformation of tert-butyloxycarbonyl-Tyr-Gly-Gly-(4-bromo)Phe-Met-OH, as a monoanionic derivative of Met-enkephalin, was elucidated by X-ray crystal analysis. The molecule took an extended conformation which was bended at the Phe residue. The implication of the dimer formation caused by 4 intermolecular hydrogen bonds was discussed in the relation with the opiate receptor.

[学科分类] 生物化学/生物物理

[关键词] Met-enkephalin analog;Anionic form;X-ray analysis;Solid state;Extended conformation;β-Sheet;Boc-Enke;tert-butyloxycarbonyl-Tyr-Gly-Gly-(4-bromo)Phe-Met-OH;Met-enkephalin;H-Tyr-Gly-Gly-Phe-Met-OH;Leu-enkephalin;H-Tyr-Gly-Gly-Phe-Leu-OH;Boc;tert-butyloxycarbonyl