The expression of mRNA for retinoic acid receptor beta (RAR-β was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-β was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-β but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-α and RAR-γ was unaffected by retinoic acid.
