Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: a computational study on glucosamine as a model solute

[摘要] Tests on animals of different species with large differences in intervertebral disc size are commonly used to investigate the therapeutic efficacy of intravenously injected solutes in the disc. We hypothesize that disc size markedly affects outcome.

[学科分类] 骨科学

[关键词] Intervertebral disc;Diffusion;Drug;Animal models;Pharmacokinetics