Efficacy of levamisole alone and in combination with mebendazole againstGongylonema pulchrum infection in rabbits

[摘要] References(18)Cited-By(1)Gongylonema pulchrum is an important parasite of captiveprimates. Twelve rabbits were infected with 30 third-stage larvae of G.pulchrum. At 4�?7 months post-infection, animals were administered levamisole ata single dose of 12 mg/kg, levamisole at 8 mg/kg three times at 2-day intervals,levamisole at a single dose of 8 mg/kg after administration of mebendazole at 70 mg/kg for3 days or 8 ml of distilled water for 3 days (control). Necropsy at 14days after treatment revealed that single and multiple dosages of levamisole reducednematode burdens by 68.4% and 89.5%, respectively. The combined regimen of mebendazole andlevamisole exhibited high efficacy for treating G. pulchrum locatedwidely within the upper digestive tract, with a reduction of 98.2%. These results suggestthat this combined chemotherapy treatment may be effective against G.pulchrum infection, including buccal and lingual gongylonemiasis inprimates.

[学科分类] 兽医学

[关键词] combined treatment;Gongylonema pulchrum;levamisole;mebendazole