In vitro efficacy of new antiprotozoals against Philasterides dicentrarchi (Ciliophora, Scuticociliatida)

[摘要] ABSTRACT: Philasterides dicentrarchi is a histiophagous ciliate that causes severe losses in turbot and sea bass farming. This study investigated the in vitro efficacy against P. dicentrarchi of 85 newly synthesized compounds and 12commercial compounds, of which 2 are fluoroquinolones (norfloxacine and lomefloxacine) with known antibacterial activity. Seventeen of the newly synthesized compounds (2 naphthyridines, 2 pyridothienodiazines and 13 pyridothienotriazines) and thefluoroquinolone norfloxacin showed good activity. The most promising compound was the pyridothienotriazine 12k, with activity similar to that of the salicylanilides niclosamide and oxiclozanide (MLC 0.8 mg l^–1 in PBS, 1.5 mgl^–1 in seawater; MLC = minimum 24 h lethal concentration).

[学科分类] 生物科学（综合）

[关键词] Philasterides dicentrarchi;Turbot;Scuticociliatosis;In vitro assay;Naphthyridines;Pyridothienotriazines;Pyridothienodiazines