Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

[摘要] Study ObjectivesTo present results from in vivo studies underlying the preclinical development of lemborexant (E2006), a novel dual orexin (hypocretin) receptor antagonist for sleep/wake regulation.

[学科分类] 生理学

[关键词] antagonist;dual orexin receptor antagonist;E2006;in vivo;insomnia;lemborexant;mouse;orexin;rat;sleep