0100 Human Sleep Spindles Coupled To Hippocampal Sharp Wave Ripples Have Characteristic EEG Features

[摘要] IntroductionSleep spindles mediate memory consolidation during sleep and are markedly reduced in schizophrenia. While spindle deficits correlate with impaired sleep-dependent memory, pharmacologically increasing spindle density in schizophrenia does not always improve memory. This may be because coupling with other NREM sleep oscillations like hippocampal sharp-wave ripples (SWRs) is required for spindles’ optimal memory benefit and those spindles induced by these drugs are not coupled with SWRs. Identifying SWR-coupled spindles cannot currently be accomplished with scalp EEG alone since it cannot detect hippocampal activity. The EPILEPSIAE dataset of simultaneously recorded scalp EEG (to detect spindles) and intracranial EEG (iEEG; to detect SWRs) presents an opportunity to identify an EEG signature of SWR-coupled spindles. This would allow SWR-spindle coupling to be evaluated noninvasively using scalp EEG alone.

[学科分类] 生理学