Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

[摘要] Study ObjectivesTo investigate the activity of brown adipose tissue (BAT) in patients with type 1 narcolepsy during cold exposure using two separate scans of sympathetic and metabolic activity of BAT to evaluate whether orexin deficiency leads to altered nonshivering thermoregulation in narcolepsy.

[学科分类] 生理学

[关键词] narcolepsy;brown adipose tissue;sympathetic nervous system;cold exposure;thermogenesis;orexin;GLP-1;FGF21;18F-FDG-PET;123I-MIBG-SPECT