INVESTIGATION ON OPTICAL, DIELECTRIC AND INVITROANTI-INFLAMMATORY RESPONSES OF TITANIUM DIOXIDE (TiO2)NANOPARTICLES

[摘要] This article deals with synthesis of titanium dioxide (TiO2) nanoparticles using sol-gelmethod. The morphological as well as optical and dielectric properties were determined.The anti-inflammatory properties of the synthesized nanoparticles were observed throughin vitro assessment. For specified concentration of TiO2 nanoparticles under restrictedexperimental conditions, the absorbance was measured to evaluate the anti-inflammatoryproperty. The morphological features and particle size with their crystal structure weredetermined by scanning electron microscopy (SEM), transmission electron microscopy(TEM) and powder X-ray diffraction (XRD). The optical properties of TiO2 nanoparticleswere measured using UV-vis. absorption spectroscopy and photoluminescence (PL)spectroscopy. The FT-IR and Raman spectra analyses were also conducted that confirmedthe presence of TiO2nanoparticles. Under predetermined frequency and temperature level,the dielectric properties including dielectric constant, dielectric loss and AC conductivityof the synthesized TiO2nanoparticles were determined. The findings indicated the antiinflammatoryproperties of TiO2 through in vitro assessment. The research also exhibitedthe inhibition of protein denaturation, protease inhibition and hemolytic assay for thesynthesized Nano particles of TiO2.

[学科分类] 生物技术

[关键词] TiO2 nanoparticles;Photoluminescence;Anti-inflammatory;Protein;denaturation