Sirtuin deacylases: a molecular link between metabolism and immunity
[摘要] LysinedeacetylationbytheNAD+‐dependentfamilyofsirtuinshasbeenrecognizedasanimportantpost‐translationalmodificationregulatingawiderangeofcellularprocesses.Theselysinedeacetylaseshaveattractedmuchinterestbasedontheirabilitytopromotesurvivalinresponsetostress.SirtuinsrequireNAD+fortheirenzymaticactivity,suggestingthattheseenzymesmayrepresentmolecularlinksbetweencellmetabolismandseveralhumandisorders,includingdiabetesandcancer.Inflammationrepresentsapathologicalsituationwithclearconnectionstometabolismandaginginhumans,raisingthepossibilitythatsirtuinsmayalsoplayanimportantroleduringanormaland/orapathologicalimmuneresponse.Agrowingbodyofdatahasconfirmedtheimmunomodulatorypropertiesofsirtuins,althoughoftenwithcontrastingandopposingconclusions.Theseobservationswillbesummarizedhereinandthepossiblestrategiesthatmayleadtothedevelopmentofnoveltherapeuticapproachestotreatinflammationbrieflydiscussed...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] NAD;SIRT1;SIRT6;inflammation;NAMPT [时效性]
