RAGE regulation and signaling in inflammation and beyond
[摘要] RAGEisakeymoleculeintheonsetandsustainmentoftheinflammatoryresponse.NewstudiesindicatethatRAGEmightrepresentanewlinkbetweentheinnateandadaptiveimmunesystem.RAGEbelongstothesuperfamilyofIgcell‐surfacereceptorsandisexpressedonalltypesofleukocytespromotingactivation,migration,ormaturationofthedifferentcells.RAGEexpressionisprominentontheactivatedendothelium,whereitmediatesleukocyteadhesionandtransmigration.Moreover,proinflammatorymoleculesreleasedfromtheinflamedorinjuredvascularsysteminducemigrationandproliferationofSMCs.RAGEbindsalargenumberofdifferentligandsandisthereforeconsideredasaPRR,recognizingastructuralmotifratherthanaspecificligand.Inthisreview,wesummarizethecurrentknowledgeaboutthesignalingpathwaysactivatedinthedifferentcelltypesanddiscussapotentialactivationmechanismofRAGE,aswellasputativeoptionsfortherapeuticintervention...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] S100;HMGB1;MAPK;NF‐κB [时效性]
